Are you tired? Fatigued? Is there a real difference?-- Yes sir- Yes ma'am there is.

Is grandpa tired or is something else going on with her? Many of us will get tired if we over exert ourselves and many of us wake up after -- not so good a night of sleep-- to be tired, but when is it more than just tired?
Obstructive sleep apnea
This is one of the most common causes of waking up tired. The passages of the upper airways collapse or are blocked by the tongue limiting the intake of fresh air. A person may stop breathing for short periods of time and this causes them to awaken thereby reducing the quality of sleep. A common symptom is awaking with a headache in the morning, loud snoring, waking up gasping for air during the course of the night and feeling sleepy throughout the day.
Acid reflux during sleep
A person with gastroesophageal reflux disease (GERD) has a weakened sphincter between the stomach and esophagus (food pipe). This allows the acidic stomach contents to flow backwards up into the esophagus, sometimes reaching as a high as the mouth and nose. It tends to worsen at night as stomach secretion rises during this time, and lying flat allows for the acid to pass up into the esophagus more easily. Heartburn is a typical symptom along with a bad taste in the mouth and sore throat upon waking.
Frequent urination at night
The need to urinate frequently at night, known as nocturia, is a common symptom of various diseases such as diabetes mellitus, prostate problems in men, urinary tract infections and overactive bladder symptom. Sometimes it is a consequence of using certain medication like diuretics for the treatment of high blood pressure. Waking up at night to urinate disrupts the sleep cycle and leads to poor quality sleep. Failure to awaken can lead to bed wetting (nocturnal enuresis).
Respiratory disease and sleep
Any cause of impaired breathing and blood oxygenation will hamper normal sleeping patterns. Chronic obstructive pulmonary disease (COPD) such as emphysema and chronic bronchitis, and secondary lung disorders like pulmonary edema (fluid in the lungs) may hamper normal breathing at night while asleep. The most common sign that this is a problem is that a person needs to sleep with more pillows as the disease worsens. Eventually a person may need to be sitting upright in order to stay asleep.

Sometimes it is simply lack of sleep, but sometimes it may be something else.  Ask questions!